SCOC (short coiled-coil protein)

2014-11-01  

Identity

HGNC
SCOC
LOCATION
4q31.1
LOCUSID
60592
ALIAS
HRIHFB2072,SCOCO,UNC-69
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60592
HGNC: 20335
Ensembl: ENSG00000153130

Variants:

dbSNP: 60592
ClinVar: 60592
TCGA: ENSG00000153130
COSMIC: SCOC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153130ENST00000338517Q9UIL1
ENSG00000153130ENST00000394201A0A0C4DGB0
ENSG00000153130ENST00000394203Q9UIL1
ENSG00000153130ENST00000394205Q9UIL1
ENSG00000153130ENST00000502535A0A0C4DGB0
ENSG00000153130ENST00000506322A0A0C4DGB0
ENSG00000153130ENST00000506597Q9UIL1
ENSG00000153130ENST00000510586A0A0C4DGB0
ENSG00000153130ENST00000512749A0A0C4DGB0
ENSG00000153130ENST00000608372Q9UIL1
ENSG00000153130ENST00000614192Q9UIL1

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
223540372012Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.46
270231752016Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.40
240984812013Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.3
241161252013Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).3

Citation

Dessen P

SCOC (short coiled-coil protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73052/scoc