SCRN1 (secernin 1)

2010-05-01  

Identity

HGNC
SCRN1
LOCATION
7p14.3
LOCUSID
9805
ALIAS
SES1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9805
MIM: 614965
HGNC: 22192
Ensembl: ENSG00000136193

Variants:

dbSNP: 9805
ClinVar: 9805
TCGA: ENSG00000136193
COSMIC: SCRN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136193ENST00000242059Q12765
ENSG00000136193ENST00000242059A0A090N7T9
ENSG00000136193ENST00000409497Q12765
ENSG00000136193ENST00000409497A0A090N7T9
ENSG00000136193ENST00000409570B8ZZP4
ENSG00000136193ENST00000421434C9K052
ENSG00000136193ENST00000425819Q12765
ENSG00000136193ENST00000425819A0A024RA21
ENSG00000136193ENST00000426154Q12765
ENSG00000136193ENST00000426154A0A090N7T9
ENSG00000136193ENST00000434476Q12765
ENSG00000136193ENST00000438497C9J7U9
ENSG00000136193ENST00000631335B8ZZP4

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203810702010Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.22
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
122211382002Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells.12
200392782010SCRN1 is a novel marker for prognosis in colorectal cancer.12
213856302011Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics.12
253999502014A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer.8
268831942016Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.3

Citation

Dessen P

SCRN1 (secernin 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51454/scrn1