SDSL (serine dehydratase like)

2014-11-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
SDH 2,SDS-RS1,TDH,cSDH
FUSION GENES

Other Information

Locus ID:

NCBI: 113675
HGNC: 30404
Ensembl: ENSG00000139410

Variants:

dbSNP: 113675
ClinVar: 113675
TCGA: ENSG00000139410
COSMIC: SDSL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139410ENST00000345635Q96GA7
ENSG00000139410ENST00000345635A0A024RBL2
ENSG00000139410ENST00000403593Q96GA7
ENSG00000139410ENST00000403593A0A024RBL2
ENSG00000139410ENST00000546672H0YID3
ENSG00000139410ENST00000547802F8VZ97
ENSG00000139410ENST00000551760H0YIA2
ENSG00000139410ENST00000553248F8VYZ3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Valine, leucine and isoleucine biosynthesisKEGGko00290
Glycine, serine and threonine metabolismKEGGhsa00260
Valine, leucine and isoleucine biosynthesisKEGGhsa00290
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
183426362008A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.3

Citation

Dessen P

SDSL (serine dehydratase like)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73076/sdsl