SEC11A (SEC11 homolog A, signal peptidase complex subunit)

2014-09-01  

Identity

HGNC
SEC11A
LOCATION
15q25.2
LOCUSID
23478
ALIAS
1810012E07Rik,SEC11L1,SPC18,SPCS4A,sid2895
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23478
MIM: 618258
HGNC: 17718
Ensembl: ENSG00000140612

Variants:

dbSNP: 23478
ClinVar: 23478
TCGA: ENSG00000140612
COSMIC: SEC11A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140612ENST00000268220P67812
ENSG00000140612ENST00000268220A0A024RC78
ENSG00000140612ENST00000455959P67812
ENSG00000140612ENST00000558134P67812
ENSG00000140612ENST00000558196H0YNX5
ENSG00000140612ENST00000558217H0YNA5
ENSG00000140612ENST00000559729H0YKT4
ENSG00000140612ENST00000560266P67812
ENSG00000140612ENST00000560409H0YNG3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Peptide hormone metabolismREACTOMER-HSA-2980736
Synthesis, secretion, and deacylation of GhrelinREACTOMER-HSA-422085
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)REACTOMER-HSA-400511
Gene ExpressionREACTOMER-HSA-74160

References

Pubmed IDYearTitleCitations
239957822014Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer.6
278599492017Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.3
311634192019SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival.0

Citation

Dessen P

SEC11A (SEC11 homolog A, signal peptidase complex subunit)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54865/sec11a