SEC16B (SEC16 homolog B, endoplasmic reticulum export factor)

2014-11-01  

Identity

HGNC
SEC16B
LOCATION
1q25.2
LOCUSID
89866
ALIAS
LZTR2,PGPR-p117,RGPR,RGPR-p117,SEC16S
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 89866
MIM: 612855
HGNC: 30301
Ensembl: ENSG00000254154

Variants:

dbSNP: 89866
ClinVar: 89866
TCGA: ENSG00000254154
COSMIC: SEC16B

RNA/Proteins

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

References

Pubmed IDYearTitleCitations
198121712010Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.74
171924112007Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.63
207245812010Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.47
202153972010Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.44
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
198513402009Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.37
198513402009Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.37
217683842011Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.31
206161992010Evaluation of genetic susceptibility loci for obesity in Chinese women.19
207129032010Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.18

Citation

Dessen P

SEC16B (SEC16 homolog B, endoplasmic reticulum export factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73085/sec16b