SELENOK (selenoprotein K)

2016-10-01  

Identity

HGNC
SELENOK
LOCATION
3p21.1
LOCUSID
58515
ALIAS
HSPC030,HSPC297,SELK

Other Information

Locus ID:

NCBI: 58515
MIM: 607916
HGNC: 30394
Ensembl: ENSG00000113811

Variants:

dbSNP: 58515
ClinVar: 58515
TCGA: ENSG00000113811
COSMIC: SELENOK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113811ENST00000488746F8WAX7
ENSG00000113811ENST00000495461Q9Y6D0
ENSG00000113811ENST00000541726F6XHT0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
212206952011Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.50
220163852011Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.33
169625882006Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.25
253681512014Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.24
251174542014Selenoprotein K form an intermolecular diselenide bond with unusually high redox potential.11
231336532012Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.10
305268722018Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.7
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5
272757612016Human MiR-544a Modulates SELK Expression in Hepatocarcinoma Cell Lines.4
267359362016Deducing the functional characteristics of the human selenoprotein SELK from the structural properties of its intrinsically disordered C-terminal domain.3

Citation

Dessen P

SELENOK (selenoprotein K)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56218/selenok