SELENOS (selenoprotein S)

2016-10-01  

Identity

HGNC
LOCATION
15q26.3
LOCUSID
ALIAS
AD-015,ADO15,SBBI8,SELS,SEPS1,VIMP

Other Information

Locus ID:

NCBI: 55829
MIM: 607918
HGNC: 30396
Ensembl: ENSG00000131871

Variants:

dbSNP: 55829
ClinVar: 55829
TCGA: ENSG00000131871
COSMIC: SELENOS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131871ENST00000398226Q9BQE4
ENSG00000131871ENST00000526049Q9BQE4
ENSG00000131871ENST00000528346E9PN30
ENSG00000131871ENST00000531964A0A182DWI4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
HRD1/SEL1 ERAD complexKEGGhsa_M00403
HRD1/SEL1 ERAD complexKEGGM00403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152158562004A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.350
162279992005Genetic variation in selenoprotein S influences inflammatory response.88
150637462004Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein.49
203786902010Genetic variants in selenoprotein genes increase risk of colorectal cancer.40
165744272006Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.35
189748422008Gender differences in genetic risk profiles for cardiovascular disease.33
176419172007Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts.29
210525282010Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer.28
193364752009Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.27
180681372008Genetic association of preeclampsia to the inflammatory response gene SEPS1.23

Citation

Dessen P

SELENOS (selenoprotein S)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56471/selenos