SELENOW (selenoprotein W)

2016-10-01  

Identity

HGNC
SELENOW
LOCATION
19q13.33
LOCUSID
6415
ALIAS
SEPW1,selW

Other Information

Locus ID:

NCBI: 6415
MIM: 603235
HGNC: 10752
Ensembl: ENSG00000178980

Variants:

dbSNP: 6415
ClinVar: 6415
TCGA: ENSG00000178980
COSMIC: SELENOW

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178980ENST00000509570F8WB74
ENSG00000178980ENST00000593892P63302
ENSG00000178980ENST00000595615P63302
ENSG00000178980ENST00000599874M0QYX1
ENSG00000178980ENST00000601048P63302
ENSG00000178980ENST00000612212A0A087WX02

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
196901922009Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma.36
306366402019PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA.17
238306272013Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis.15
156708482005Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon.11
158235562005Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion.11
218755732011Delayed cell cycle progression from SEPW1 depletion is p53- and p21-dependent in MCF-7 breast cancer cells.11
193875672009Selenoprotein W modulates control of cell cycle entry.10
227303272012Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.10
218665682012Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells.8
257217652015Selenoprotein W controls epidermal growth factor receptor surface expression, activation and degradation via receptor ubiquitination.6

Citation

Dessen P

SELENOW (selenoprotein W)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56195/selenow