SELPLG (selectin P ligand)

2003-11-01  

Identity

HGNC
SELPLG
LOCATION
12q24.11
LOCUSID
6404
ALIAS
CD162,CLA,PSGL-1,PSGL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6404
MIM: 600738
HGNC: 10722
Ensembl: ENSG00000110876

Variants:

dbSNP: 6404
ClinVar: 6404
TCGA: ENSG00000110876
COSMIC: SELPLG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110876ENST00000228463Q14242
ENSG00000110876ENST00000388962A0A0C4DFY0
ENSG00000110876ENST00000550948Q14242

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127366892003Direct observation of catch bonds involving cell-adhesion molecules.305
165472812006The vast majority of CLA+ T cells are resident in normal skin.209
195432842009Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.174
220213702011Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.152
145079292003The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
119168432002Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters.67
178273882007Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.67
204450172010Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils.66
185090852008Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles.65

Citation

Dessen P

SELPLG (selectin P ligand)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42251/selplg