SEMA3A (semaphorin 3A)

2007-02-01  

Identity

HGNC
LOCATION
7q21.11
LOCUSID
ALIAS
COLL1,HH16,Hsema-I,Hsema-III,SEMA1,SEMAD,SEMAIII,SEMAL,SemD,coll-1
FUSION GENES

Other Information

Locus ID:

NCBI: 10371
MIM: 603961
HGNC: 10723
Ensembl: ENSG00000075213

Variants:

dbSNP: 10371
ClinVar: 10371
TCGA: ENSG00000075213
COSMIC: SEMA3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075213ENST00000265362Q14563
ENSG00000075213ENST00000420047C9J9C4
ENSG00000075213ENST00000424555C9JD25
ENSG00000075213ENST00000436949Q14563
ENSG00000075213ENST00000448879A0A0C4DG50

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128790612003Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function.182
145003502003Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.78
175696712007Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis.75
176079422007The CRMP family of proteins and their role in Sema3A signaling.72
179896952007Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
188187662008Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.49
167918962006Immunosuppressive role of semaphorin-3A on T cell proliferation is mediated by inhibition of actin cytoskeleton reorganization.47
196846142009Autocrine semaphorin 3A signaling promotes glioblastoma dispersal.47
173900262007Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells.46

Citation

Dessen P

SEMA3A (semaphorin 3A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43720/sema3a