SEMA3E (semaphorin 3E)

2007-02-01  

Identity

HGNC
SEMA3E
LOCATION
7q21.11
LOCUSID
9723
ALIAS
M-SEMAH,M-SemaK,SEMAH,coll-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9723
MIM: 608166
HGNC: 10727
Ensembl: ENSG00000170381

Variants:

dbSNP: 9723
ClinVar: 9723
TCGA: ENSG00000170381
COSMIC: SEMA3E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170381ENST00000427262O15041
ENSG00000170381ENST00000453333F8WCZ5
ENSG00000170381ENST00000642232A0A2R8YCX5
ENSG00000170381ENST00000643230O15041

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
215052592011Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.70
206641712010Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
188187662008Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.49
241398592013Semaphorin 3E suppresses tumor cell death triggered by the plexin D1 dependence receptor in metastatic breast cancers.35
152350372004SEMA3E mutation in a patient with CHARGE syndrome.33
217957012011Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.26
222470102012Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.26
248258962014Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways.26

Citation

Dessen P

SEMA3E (semaphorin 3E)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46233/sema3e