SENP1 (SUMO specific peptidase 1)

2003-06-01  

Identity

HGNC
LOCATION
12q13.11
LOCUSID
ALIAS
SuPr-2
FUSION GENES

Other Information

Locus ID:

NCBI: 29843
MIM: 612157
HGNC: 17927
Ensembl: ENSG00000079387

Variants:

dbSNP: 29843
ClinVar: 29843
TCGA: ENSG00000079387
COSMIC: SENP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079387ENST00000448372Q9P0U3
ENSG00000079387ENST00000549518Q9P0U3
ENSG00000079387ENST00000549595Q9P0U3
ENSG00000079387ENST00000551798F8VRZ8
ENSG00000079387ENST00000552189F8W0I8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is proteolytically processedREACTOMER-HSA-3065679

References

Pubmed IDYearTitleCitations
379141452024SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription.1
380116712024EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signalling†.0
381846502024A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.0
381863032024SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.4
383744072024METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.1
388030012024SENP1-Mediated deSUMOylation Regulates the Tumor Remodeling of Glioma Stem Cells Under Hypoxic Stress.0
388223512024N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2.1
379141452024SENP1 knockdown-mediated CTCF SUMOylation enhanced its stability and alleviated lipopolysaccharide-evoked inflammatory injury in human lung fibroblasts via regulation of FOXA2 transcription.1
380116712024EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signalling†.0
381846502024A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.0
381863032024SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.4
383744072024METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.1
388030012024SENP1-Mediated deSUMOylation Regulates the Tumor Remodeling of Glioma Stem Cells Under Hypoxic Stress.0
388223512024N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2.1
359426122023SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization.8

Citation

Dessen P

SENP1 (SUMO specific peptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42258/senp1