SENP3 (SUMO specific peptidase 3)

2010-06-01 Affiliation

Identity

HGNC

SENP3

LOCATION

17p13.1

LOCUSID

26168

ALIAS

SMT3IP1,SSP3,Ulp1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26168
MIM: 612844
HGNC: 17862
Ensembl: ENSG00000161956

Variants:

dbSNP: 26168
ClinVar: 26168
TCGA: ENSG00000161956
COSMIC: SENP3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000161956	ENST00000321337	Q9H4L4
ENSG00000161956	ENST00000429205	Q9H4L4
ENSG00000161956	ENST00000580231	J3QL36
ENSG00000161956	ENST00000581093	J3KSF5
ENSG00000161956	ENST00000582789	J3QRE4
ENSG00000161956	ENST00000610454	A0A087WV50
ENSG00000161956	ENST00000619785	A0A087WZ63

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	29382897
PA450464	methylphenidate	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	29382897

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19680224	2009	SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.	56
23524851	2013	SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.	55
18259216	2008	The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.	54
18946085	2009	RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.	42
19015314	2008	Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.	39
20181954	2010	SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.	34
20924358	2010	Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90.	33
22872859	2012	Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.	26
19423540	2009	Common variation in genes related to innate immunity and risk of adult glioma.	19

Citation

Dessen P

SENP3 (SUMO specific peptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51505/senp3