SENP8 (SUMO peptidase family member, NEDD8 specific)

2014-11-01  

Identity

HGNC
SENP8
LOCATION
15q23
LOCUSID
123228
ALIAS
DEN1,NEDP1,PRSC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 123228
MIM: 608659
HGNC: 22992
Ensembl: ENSG00000166192

Variants:

dbSNP: 123228
ClinVar: 123228
TCGA: ENSG00000166192
COSMIC: SENP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166192ENST00000340912Q96LD8
ENSG00000166192ENST00000542035Q96LD8
ENSG00000166192ENST00000564082H3BTK5
ENSG00000166192ENST00000564863H3BS71
ENSG00000166192ENST00000567794H3BTJ8

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127302212003NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins.65
127593632003DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.65
155674172005Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1.34
232093202013Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response.22
234089082013Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.17
197840692010Chemotherapy induces NEDP1-mediated destabilization of MDM2.16
230010412013NEDDylation controls the target specificity of E2F1 and apoptosis induction.15
284750372017SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.12
256559322015NEDDylation promotes endothelial dysfunction: a role for HDAC2.7
221107502011The molecular determinants of NEDD8 specific recognition by human SENP8.5

Citation

Dessen P

SENP8 (SUMO peptidase family member, NEDD8 specific)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73118/senp8