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SENP8 (SUMO peptidase family member, NEDD8 specific)

Identity

Alias_namesPRSC2
protease, cysteine, 2 (NEDD8 specific)
SUMO/sentrin specific protease family member 8
SUMO/sentrin specific peptidase family member 8
Alias_symbol (synonym)NEDP1
DEN1
HsT17512
Other alias
HGNC (Hugo) SENP8
LocusID (NCBI) 123228
Atlas_Id 73118
Location 15q23  [Link to chromosome band 15q23]
Location_base_pair Starts at 72114258 and ends at 72140970 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SMAD3 (15q22.33) / SENP8 (15q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SENP8   22992
Cards
Entrez_Gene (NCBI)SENP8  123228  SUMO peptidase family member, NEDD8 specific
AliasesDEN1; NEDP1; PRSC2
GeneCards (Weizmann)SENP8
Ensembl hg19 (Hinxton)ENSG00000166192 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166192 [Gene_View]  ENSG00000166192 [Sequence]  chr15:72114258-72140970 [Contig_View]  SENP8 [Vega]
ICGC DataPortalENSG00000166192
TCGA cBioPortalSENP8
AceView (NCBI)SENP8
Genatlas (Paris)SENP8
WikiGenes123228
SOURCE (Princeton)SENP8
Genetics Home Reference (NIH)SENP8
Genomic and cartography
GoldenPath hg38 (UCSC)SENP8  -     chr15:72114258-72140970 +  15q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SENP8  -     15q23   [Description]    (hg19-Feb_2009)
GoldenPathSENP8 - 15q23 [CytoView hg19]  SENP8 - 15q23 [CytoView hg38]
ImmunoBaseENSG00000166192
Mapping of homologs : NCBISENP8 [Mapview hg19]  SENP8 [Mapview hg38]
OMIM608659   
Gene and transcription
Genbank (Entrez)AF308450 AK097557 AK292298 AY008293 BC031411
RefSeq transcript (Entrez)NM_001166340 NM_001172109 NM_001172110 NM_001172111 NM_145204
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SENP8
Cluster EST : UnigeneHs.513002 [ NCBI ]
CGAP (NCI)Hs.513002
Alternative Splicing GalleryENSG00000166192
Gene ExpressionSENP8 [ NCBI-GEO ]   SENP8 [ EBI - ARRAY_EXPRESS ]   SENP8 [ SEEK ]   SENP8 [ MEM ]
Gene Expression Viewer (FireBrowse)SENP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)123228
GTEX Portal (Tissue expression)SENP8
Human Protein AtlasENSG00000166192-SENP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96LD8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96LD8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96LD8
Splice isoforms : SwissVarQ96LD8
PhosPhoSitePlusQ96LD8
Domaine pattern : Prosite (Expaxy)ULP_PROTEASE (PS50600)   
Domains : Interpro (EBI)Peptidase_C48_C   
Domain families : Pfam (Sanger)Peptidase_C48 (PF02902)   
Domain families : Pfam (NCBI)pfam02902   
Conserved Domain (NCBI)SENP8
DMDM Disease mutations123228
Blocks (Seattle)SENP8
PDB (RSDB)1XT9    2BKQ    2BKR   
PDB Europe1XT9    2BKQ    2BKR   
PDB (PDBSum)1XT9    2BKQ    2BKR   
PDB (IMB)1XT9    2BKQ    2BKR   
Structural Biology KnowledgeBase1XT9    2BKQ    2BKR   
SCOP (Structural Classification of Proteins)1XT9    2BKQ    2BKR   
CATH (Classification of proteins structures)1XT9    2BKQ    2BKR   
SuperfamilyQ96LD8
Human Protein Atlas [tissue]ENSG00000166192-SENP8 [tissue]
Peptide AtlasQ96LD8
HPRD09784
IPIIPI00165616   
Protein Interaction databases
DIP (DOE-UCLA)Q96LD8
IntAct (EBI)Q96LD8
FunCoupENSG00000166192
BioGRIDSENP8
STRING (EMBL)SENP8
ZODIACSENP8
Ontologies - Pathways
QuickGOQ96LD8
Ontology : AmiGOcytosol  protein deubiquitination  NEDD8-specific protease activity  post-translational protein modification  
Ontology : EGO-EBIcytosol  protein deubiquitination  NEDD8-specific protease activity  post-translational protein modification  
NDEx NetworkSENP8
Atlas of Cancer Signalling NetworkSENP8
Wikipedia pathwaysSENP8
Orthology - Evolution
OrthoDB123228
GeneTree (enSembl)ENSG00000166192
Phylogenetic Trees/Animal Genes : TreeFamSENP8
HOGENOMQ96LD8
Homologs : HomoloGeneSENP8
Homology/Alignments : Family Browser (UCSC)SENP8
Gene fusions - Rearrangements
Fusion : QuiverSENP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSENP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SENP8
dbVarSENP8
ClinVarSENP8
1000_GenomesSENP8 
Exome Variant ServerSENP8
ExAC (Exome Aggregation Consortium)ENSG00000166192
GNOMAD BrowserENSG00000166192
Varsome BrowserSENP8
Genetic variants : HAPMAP123228
Genomic Variants (DGV)SENP8 [DGVbeta]
DECIPHERSENP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSENP8 
Mutations
ICGC Data PortalSENP8 
TCGA Data PortalSENP8 
Broad Tumor PortalSENP8
OASIS PortalSENP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSENP8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSENP8
Mutations and Diseases : HGMDSENP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SENP8
DgiDB (Drug Gene Interaction Database)SENP8
DoCM (Curated mutations)SENP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SENP8 (select a term)
intoGenSENP8
Cancer3DSENP8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608659   
Orphanet
DisGeNETSENP8
MedgenSENP8
Genetic Testing Registry SENP8
NextProtQ96LD8 [Medical]
TSGene123228
GENETestsSENP8
Target ValidationSENP8
Huge Navigator SENP8 [HugePedia]
snp3D : Map Gene to Disease123228
BioCentury BCIQSENP8
ClinGenSENP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD123228
Chemical/Pharm GKB GenePA134866772
Clinical trialSENP8
Miscellaneous
canSAR (ICR)SENP8 (select the gene name)
DataMed IndexSENP8
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSENP8
EVEXSENP8
GoPubMedSENP8
iHOPSENP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 16:04:54 CEST 2019
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