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SERINC2 (serine incorporator 2)

Identity

Alias_namesTDE2L
tumor differentially expressed 2-like
Alias_symbol (synonym)FKSG84
PRO0899
TDE2
Other alias
HGNC (Hugo) SERINC2
LocusID (NCBI) 347735
Atlas_Id 42504
Location 1p35.2  [Link to chromosome band 1p35]
Location_base_pair Starts at 31413116 and ends at 31434680 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HDAC1 (1p35.1) / SERINC2 (1p35.2)MTF1 (1p34.3) / SERINC2 (1p35.2)RCC1 (1p35.3) / SERINC2 (1p35.2)
SBNO2 (19p13.3) / SERINC2 (1p35.2)SERINC2 (1p35.2) / ACY1 (3p21.2)SERINC2 (1p35.2) / ARHGAP1 (11p11.2)
SERINC2 (1p35.2) / ARHGEF1 (19q13.2)SERINC2 (1p35.2) / SERINC2 (1p35.2)SERINC2 (1p35.2) / ZCCHC17 (1p35.2)
SERINC2 (1p35.2) / ZNFX1 (20q13.13)TRPM4 (19q13.33) / SERINC2 (1p35.2)ZCCHC17 (1p35.2) / SERINC2 (1p35.2)
HDAC1 1p35.1 / SERINC2 1p35.2MTF1 1p34.3 / SERINC2 1p35.2RCC1 1p35.3 / SERINC2 1p35.2
SBNO2 19p13.3 / SERINC2 1p35.2SERINC2 1p35.2 / ARHGEF1 19q13.2SERINC2 1p35.2 / ZCCHC17 1p35.2
SERINC2 1p35.2 / ZNFX1 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  Lung: Translocations in Small Cell Carcinoma
t(1;1)(p34;p35) MTF1/SERINC2
HDAC1/SERINC2 (1p35)
RCC1/SERINC2 (1p35)
SERINC2/ZCCHC17 (1p35)
t(1;19)(p35;p13) SBNO2/SERINC2
t(1;19)(p35;q13) SERINC2/ARHGEF1
t(1;20)(p35;q13) SERINC2/ZNFX1


External links

Nomenclature
HGNC (Hugo)SERINC2   23231
Cards
Entrez_Gene (NCBI)SERINC2  347735  serine incorporator 2
AliasesFKSG84; PRO0899; TDE2; TDE2L
GeneCards (Weizmann)SERINC2
Ensembl hg19 (Hinxton)ENSG00000168528 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168528 [Gene_View]  ENSG00000168528 [Sequence]  chr1:31413116-31434680 [Contig_View]  SERINC2 [Vega]
ICGC DataPortalENSG00000168528
TCGA cBioPortalSERINC2
AceView (NCBI)SERINC2
Genatlas (Paris)SERINC2
WikiGenes347735
SOURCE (Princeton)SERINC2
Genetics Home Reference (NIH)SERINC2
Genomic and cartography
GoldenPath hg38 (UCSC)SERINC2  -     chr1:31413116-31434680 +  1p35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SERINC2  -     1p35.2   [Description]    (hg19-Feb_2009)
GoldenPathSERINC2 - 1p35.2 [CytoView hg19]  SERINC2 - 1p35.2 [CytoView hg38]
ImmunoBaseENSG00000168528
Mapping of homologs : NCBISERINC2 [Mapview hg19]  SERINC2 [Mapview hg38]
OMIM614549   
Gene and transcription
Genbank (Entrez)AF116607 AF352325 AK093784 AK127659 AK296118
RefSeq transcript (Entrez)NM_001199037 NM_001199038 NM_001199039 NM_018565 NM_178865
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SERINC2
Cluster EST : UnigeneHs.270655 [ NCBI ]
CGAP (NCI)Hs.270655
Alternative Splicing GalleryENSG00000168528
Gene ExpressionSERINC2 [ NCBI-GEO ]   SERINC2 [ EBI - ARRAY_EXPRESS ]   SERINC2 [ SEEK ]   SERINC2 [ MEM ]
Gene Expression Viewer (FireBrowse)SERINC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)347735
GTEX Portal (Tissue expression)SERINC2
Human Protein AtlasENSG00000168528-SERINC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SA4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SA4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SA4
Splice isoforms : SwissVarQ96SA4
PhosPhoSitePlusQ96SA4
Domains : Interpro (EBI)SERINC2    TDE1/TMS   
Domain families : Pfam (Sanger)Serinc (PF03348)   
Domain families : Pfam (NCBI)pfam03348   
Conserved Domain (NCBI)SERINC2
DMDM Disease mutations347735
Blocks (Seattle)SERINC2
SuperfamilyQ96SA4
Human Protein Atlas [tissue]ENSG00000168528-SERINC2 [tissue]
Peptide AtlasQ96SA4
HPRD15481
IPIIPI00329283   IPI00292667   IPI00984199   IPI00985317   IPI00981477   IPI00643476   
Protein Interaction databases
DIP (DOE-UCLA)Q96SA4
IntAct (EBI)Q96SA4
FunCoupENSG00000168528
BioGRIDSERINC2
STRING (EMBL)SERINC2
ZODIACSERINC2
Ontologies - Pathways
QuickGOQ96SA4
Ontology : AmiGOphosphatidylserine metabolic process  sphingolipid metabolic process  integral component of membrane  extracellular exosome  positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity  positive regulation of serine C-palmitoyltransferase activity  
Ontology : EGO-EBIphosphatidylserine metabolic process  sphingolipid metabolic process  integral component of membrane  extracellular exosome  positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity  positive regulation of serine C-palmitoyltransferase activity  
NDEx NetworkSERINC2
Atlas of Cancer Signalling NetworkSERINC2
Wikipedia pathwaysSERINC2
Orthology - Evolution
OrthoDB347735
GeneTree (enSembl)ENSG00000168528
Phylogenetic Trees/Animal Genes : TreeFamSERINC2
HOGENOMQ96SA4
Homologs : HomoloGeneSERINC2
Homology/Alignments : Family Browser (UCSC)SERINC2
Gene fusions - Rearrangements
Fusion : MitelmanHDAC1/SERINC2 [1p35.1/1p35.2]  [t(1;1)(p35;p35)]  
Fusion : MitelmanMTF1/SERINC2 [1p34.3/1p35.2]  [t(1;1)(p34;p35)]  
Fusion : MitelmanRCC1/SERINC2 [1p35.3/1p35.2]  [t(1;1)(p35;p35)]  
Fusion : MitelmanSBNO2/SERINC2 [19p13.3/1p35.2]  [t(1;19)(p35;p13)]  
Fusion : MitelmanSERINC2/ARHGEF1 [1p35.2/19q13.2]  [t(1;19)(p35;q13)]  
Fusion : MitelmanSERINC2/ZCCHC17 [1p35.2/1p35.2]  [t(1;1)(p35;p35)]  
Fusion : MitelmanSERINC2/ZNFX1 [1p35.2/20q13.13]  [t(1;20)(p35;q13)]  
Fusion PortalHDAC1 1p35.1 SERINC2 1p35.2 GBM
Fusion PortalMTF1 1p34.3 SERINC2 1p35.2 KIRC
Fusion PortalRCC1 1p35.3 SERINC2 1p35.2 HNSC
Fusion PortalSBNO2 19p13.3 SERINC2 1p35.2 BRCA
Fusion PortalSERINC2 1p35.2 ARHGEF1 19q13.2 BRCA
Fusion PortalSERINC2 1p35.2 ZCCHC17 1p35.2 LUSC
Fusion PortalSERINC2 1p35.2 ZNFX1 20q13.13 LUAD
Fusion : QuiverSERINC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSERINC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SERINC2
dbVarSERINC2
ClinVarSERINC2
1000_GenomesSERINC2 
Exome Variant ServerSERINC2
ExAC (Exome Aggregation Consortium)ENSG00000168528
GNOMAD BrowserENSG00000168528
Varsome BrowserSERINC2
Genetic variants : HAPMAP347735
Genomic Variants (DGV)SERINC2 [DGVbeta]
DECIPHERSERINC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSERINC2 
Mutations
ICGC Data PortalSERINC2 
TCGA Data PortalSERINC2 
Broad Tumor PortalSERINC2
OASIS PortalSERINC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSERINC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSERINC2
Mutations and Diseases : HGMDSERINC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SERINC2
DgiDB (Drug Gene Interaction Database)SERINC2
DoCM (Curated mutations)SERINC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SERINC2 (select a term)
intoGenSERINC2
Cancer3DSERINC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614549   
Orphanet
DisGeNETSERINC2
MedgenSERINC2
Genetic Testing Registry SERINC2
NextProtQ96SA4 [Medical]
TSGene347735
GENETestsSERINC2
Target ValidationSERINC2
Huge Navigator SERINC2 [HugePedia]
snp3D : Map Gene to Disease347735
BioCentury BCIQSERINC2
ClinGenSERINC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD347735
Chemical/Pharm GKB GenePA134933002
Clinical trialSERINC2
Miscellaneous
canSAR (ICR)SERINC2 (select the gene name)
DataMed IndexSERINC2
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSERINC2
EVEXSERINC2
GoPubMedSERINC2
iHOPSERINC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:06:50 CET 2019

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