SERP1 (stress associated endoplasmic reticulum protein 1)

2012-10-01  

Identity

HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
RAMP4
FUSION GENES

Other Information

Locus ID:

NCBI: 27230
MIM: 617674
HGNC: 10759
Ensembl: ENSG00000120742

Variants:

dbSNP: 27230
ClinVar: 27230
TCGA: ENSG00000120742
COSMIC: SERP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120742ENST00000239944Q9Y6X1
ENSG00000120742ENST00000479209Q9Y6X1
ENSG00000120742ENST00000487153C9JSB0
ENSG00000120742ENST00000491660C9JUH5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
257198022015Diagnostic value of SFRP1 as a favorable predictive and prognostic biomarker in patients with prostate cancer.19
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
224191282012SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence.8
225264582012Regulation of ENaC biogenesis by the stress response protein SERP1.6
289023582017SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis.2
295448802018Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.2

Citation

Dessen P

SERP1 (stress associated endoplasmic reticulum protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52906/serp1