SERPINA5 (serpin family A member 5)

2007-02-01 Affiliation

Identity

HGNC

SERPINA5

LOCATION

14q32.13

LOCUSID

5104

ALIAS

PAI-3,PAI3,PCI,PCI-B,PLANH3,PROCI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5104
MIM: 601841
HGNC: 8723
Ensembl: ENSG00000188488

Variants:

dbSNP: 5104
ClinVar: 5104
TCGA: ENSG00000188488
COSMIC: SERPINA5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188488	ENST00000329597	P05154
ENSG00000188488	ENST00000329597	A0A024R6N9
ENSG00000188488	ENST00000553511	G3V3F5
ENSG00000188488	ENST00000553780	P05154
ENSG00000188488	ENST00000553780	A0A024R6N9
ENSG00000188488	ENST00000554220	G3V264
ENSG00000188488	ENST00000554276	P05154
ENSG00000188488	ENST00000554276	A0A024R6N9
ENSG00000188488	ENST00000554633	G3V4B4
ENSG00000188488	ENST00000554866	P05154
ENSG00000188488	ENST00000554866	A0A024R6N9
ENSG00000188488	ENST00000555681	G3V482
ENSG00000188488	ENST00000556064	G3V3Y3
ENSG00000188488	ENST00000556775	G3V2M1
ENSG00000188488	ENST00000557598	G3V265

Expression (GTEx)

100

150

200

250

300

350

400

450

500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
Hemostasis	REACTOME	R-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Intrinsic Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140837
Common Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140875

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated	PD	31616045
PA445846	Thrombocytopenia	Disease	ClinicalAnnotation	associated	PD	31616045
PA448803	carboplatin	Chemical	ClinicalAnnotation	associated	PD	31616045
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated	PD	31616045

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18362344	2008	Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.	17
20019810	2009	Protein C inhibitor--a novel antimicrobial agent.	14
24388360	2014	SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma.	14
17332248	2007	Regulation of protein C inhibitor (PCI) activity by specific oxidized and negatively charged phospholipids.	13
14696115	2004	Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma.	11
17450526	2007	Protein C inhibitor inhibits breast cancer cell growth, metastasis and angiogenesis independently of its protease inhibitory activity.	11
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
11161981	2001	A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis.	10
17258797	2007	Expression of plasminogen activator inhibitors type 1 and type 3 and urokinase plasminogen activator protein and mRNA in breast cancer.	10

Citation

Dessen P

SERPINA5 (serpin family A member 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43985/serpina5