SERPINB1 (serpin family B member 1)

2014-09-01  

Identity

HGNC
LOCATION
6p25.2
LOCUSID
ALIAS
EI,ELANH2,HEL-S-27,HEL57,LEI,M/NEI,MNEI,PI-2,PI2
FUSION GENES

Other Information

Locus ID:

NCBI: 1992
MIM: 130135
HGNC: 3311
Ensembl: ENSG00000021355

Variants:

dbSNP: 1992
ClinVar: 1992
TCGA: ENSG00000021355
COSMIC: SERPINB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000021355ENST00000380739P30740
ENSG00000021355ENST00000380739V9HWH1

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
117474532001The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites.40
230024422012A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation.37
212481492011SerpinB1 protects the mature neutrophil reserve in the bone marrow.23
299679392018Sex-specific genetic predictors of Alzheimer's disease biomarkers.14
249680892015Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells.13
204854442010Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.9
224216202012Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis.8
232692432013Identification of SERPINB1 as a physiological inhibitor of human granzyme H.8
241052722014Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma.8
306926212019SERPINB1-mediated checkpoint of inflammatory caspase activation.8

Citation

Dessen P

SERPINB1 (serpin family B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54855/serpinb1