SERPINB13 (serpin family B member 13)

2007-02-01  

Identity

HGNC
SERPINB13
LOCATION
18q21.33
LOCUSID
5275
ALIAS
HSHUR7SEQ,HUR7,PI13,headpin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5275
MIM: 604445
HGNC: 8944
Ensembl: ENSG00000197641

Variants:

dbSNP: 5275
ClinVar: 5275
TCGA: ENSG00000197641
COSMIC: SERPINB13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197641ENST00000269489A0A0A0MQW3
ENSG00000197641ENST00000344731Q9UIV8
ENSG00000197641ENST00000415733H7BZS9
ENSG00000197641ENST00000431153C9JL93
ENSG00000197641ENST00000438844F8WE70

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
128094932003Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis.17
164336822006Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.9
196908902009Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.9
125049042003Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis.8
163571592005Headpin: a serpin with endogenous and exogenous suppression of angiogenesis.8
195692402009Downregulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome.7
158850772005Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas.3
225936142012Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.3
217232532011SERPINB13 is a novel RUNX1 target gene.2

Citation

Dessen P

SERPINB13 (serpin family B member 13)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45574/serpinb13