SERPINB4 (serpin family B member 4)

2003-02-01  

Identity

HGNC
SERPINB4
LOCATION
18q21.33
LOCUSID
6318
ALIAS
LEUPIN,PI11,SCCA-2,SCCA1,SCCA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6318
MIM: 600518
HGNC: 10570
Ensembl: ENSG00000206073

Variants:

dbSNP: 6318
ClinVar: 6318
TCGA: ENSG00000206073
COSMIC: SERPINB4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000206073ENST00000341074P48594
ENSG00000206073ENST00000413673H0Y5H9
ENSG00000206073ENST00000436264C9JZ65

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
276686552016Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.32
149708612004Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.27
165494982006Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.24
229378092012Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma.22
215763552011Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.18
252133222014SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling.17
199594742010Heparin enhances serpin inhibition of the cysteine protease cathepsin L.14
218579422011Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.14
156774602005Uteroglobin suppresses SCCA gene expression associated with allergic asthma.13
251116162015SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.13

Citation

Dessen P

SERPINB4 (serpin family B member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42266/serpinb4