SERPINE1 (serpin family E member 1)

2003-02-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
PAI,PAI-1,PAI1,PLANH1
FUSION GENES

Other Information

Locus ID:

NCBI: 5054
MIM: 173360
HGNC: 8583
Ensembl: ENSG00000106366

Variants:

dbSNP: 5054
ClinVar: 5054
TCGA: ENSG00000106366
COSMIC: SERPINE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106366ENST00000223095P05121
ENSG00000106366ENST00000223095A0A024QYT5

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
Complement and coagulation cascadesKEGGko04610
p53 signaling pathwayKEGGhsa04115
Complement and coagulation cascadesKEGGhsa04610
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
HIF-1 signaling pathwayKEGGhsa04066
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Dissolution of Fibrin ClotREACTOMER-HSA-75205
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD18285546
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD18794724
PA449015citalopramChemicalClinicalAnnotationassociatedPD18794724
PA449247dexamethasoneChemicalClinicalAnnotationassociatedPD18285546
PA449673fluoxetineChemicalClinicalAnnotationassociatedPD18794724
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD18794724

References

Pubmed IDYearTitleCitations
124779412002Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.102
161020552005PAI-1 and atherothrombosis.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
195015812009Hepatic insulin resistance, metabolic syndrome and cardiovascular disease.81
158413062005Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.79
156342642005Pleiotropic functions of plasminogen activator inhibitor-1.76
150015792004The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.73
205195072010Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.59
191769912008The plasminogen activator system and cancer.54
119099932002Plasminogen activator inhibitor 1: physiological and pathophysiological roles.52

Citation

Dessen P

SERPINE1 (serpin family E member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/404/serpine1