SERPINF2 (serpin family F member 2)

2007-07-01  

Identity

HGNC
SERPINF2
LOCATION
17p13.3
LOCUSID
5345
ALIAS
A2AP,AAP,ALPHA-2-PI,API,PLI,alpha2AP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5345
MIM: 613168
HGNC: 9075
Ensembl: ENSG00000167711

Variants:

dbSNP: 5345
ClinVar: 5345
TCGA: ENSG00000167711
COSMIC: SERPINF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167711ENST00000324015P08697
ENSG00000167711ENST00000382061P08697
ENSG00000167711ENST00000450523P08697
ENSG00000167711ENST00000453066C9JMH6
ENSG00000167711ENST00000453723C9JPV4

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Dissolution of Fibrin ClotREACTOMER-HSA-75205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
190738252009Plasmin in nephrotic urine activates the epithelial sodium channel.80
200713282010Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D.38
214869492011Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption.31
214715212011The antifibrinolytic function of factor XIII is exclusively expressed through α₂-antiplasmin cross-linking.29
185507042008Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.24
253311182014Functional factor XIII-A is exposed on the stimulated platelet surface.21
173888012007TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots.20
239924062013Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis).13
266269942016Natural heterogeneity of α2-antiplasmin: functional and clinical consequences.13

Citation

Dessen P

SERPINF2 (serpin family F member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47650/serpinf2