SERTAD1 (SERTA domain containing 1)

2007-02-01  

Identity

HGNC
SERTAD1
LOCATION
19q13.2
LOCUSID
29950
ALIAS
SEI1,TRIP-Br1,TRIPBR1

Other Information

Locus ID:

NCBI: 29950
MIM: 617850
HGNC: 17932
Ensembl: ENSG00000197019

Variants:

dbSNP: 29950
ClinVar: 29950
TCGA: ENSG00000197019
COSMIC: SERTAD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197019ENST00000357949Q9UHV2
ENSG00000197019ENST00000357949Q53GC0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
239700322013Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.22
146756342003The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1.14
150658842004The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner.11
205708972010Characterization of a novel mechanism of genomic instability involving the SEI1/SET/NM23H1 pathway in esophageal cancers.11
210443672010An integrative method for scoring candidate genes from association studies: application to warfarin dosing.11
217252082011p34 (SEI-1) inhibits ROS-induced cell death through suppression of ASK1.9
162017502005Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).8
263349582015TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition.5
247896582014Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells.4
276976112017SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.4

Citation

Dessen P

SERTAD1 (SERTA domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45880/sertad1