SESN3 (sestrin 3)

2016-10-01 Affiliation

Identity

HGNC

SESN3

LOCATION

11q21

LOCUSID

143686

ALIAS

SEST3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 143686
MIM: 607768
HGNC: 23060
Ensembl: ENSG00000149212

Variants:

dbSNP: 143686
ClinVar: 143686
TCGA: ENSG00000149212
COSMIC: SESN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149212	ENST00000278499	P58005
ENSG00000149212	ENST00000416495	P58005
ENSG00000149212	ENST00000536441	P58005
ENSG00000149212	ENST00000542176	F5H1K7
ENSG00000149212	ENST00000634898	A0A0U1RR17

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
p53 signaling pathway	KEGG	hsa04115
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Longevity regulating pathway	KEGG	hsa04211

References

Pubmed ID	Year	Title	Citations
20412774	2010	The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease.	121
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
25615886	2015	Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.	44
23388456	2013	Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways.	20
24129397	2013	Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle.	9
24833709	2014	The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury.	7
28869600	2017	FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3.	7
24260131	2013	Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.	5
29191771	2018	Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.	5
29966750	2018	Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging.	5

Citation

Dessen P

SESN3 (sestrin 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56562/sesn3