SETD7 (SET domain containing 7, histone lysine methyltransferase)

2007-02-01  

Identity

HGNC
SETD7
LOCATION
4q31.1
LOCUSID
80854
ALIAS
KMT7,SET7,SET7/9,SET9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80854
MIM: 606594
HGNC: 30412
Ensembl: ENSG00000145391

Variants:

dbSNP: 80854
ClinVar: 80854
TCGA: ENSG00000145391
COSMIC: SETD7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145391ENST00000274031Q8WTS6
ENSG00000145391ENST00000404104B5MCZ8
ENSG00000145391ENST00000406354B5MCS2
ENSG00000145391ENST00000506866D6RJA0
ENSG00000145391ENST00000608795V9GYG1
ENSG00000145391ENST00000608958V9GY19

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
FoxO signaling pathwayKEGGhsa04068
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126708682003Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.193
117794972001Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.179
125408552003Structure and catalytic mechanism of the human histone methyltransferase SET7/9.141
210986642010Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.118
186504212008Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation.116
184719792008Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.112
192824822009Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.112
192625652009Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.87
123723042002Crystal structure and functional analysis of the histone methyltransferase SET7/9.73
176463892007Methylation-acetylation interplay activates p53 in response to DNA damage.71

Citation

Dessen P

SETD7 (SET domain containing 7, histone lysine methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50018/setd7