SETMAR (SET domain and mariner transposase fusion gene)

2007-02-01  

Identity

HGNC
SETMAR
LOCATION
3p26.1
LOCUSID
6419
ALIAS
METNASE,Mar1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6419
MIM: 609834
HGNC: 10762
Ensembl: ENSG00000170364

Variants:

dbSNP: 6419
ClinVar: 6419
TCGA: ENSG00000170364
COSMIC: SETMAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170364ENST00000358065Q53H47
ENSG00000170364ENST00000358950B9ZVV8
ENSG00000170364ENST00000413809F8WEU1
ENSG00000170364ENST00000425046F8WB33
ENSG00000170364ENST00000425863Q53H47
ENSG00000170364ENST00000430981Q53H47

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310

References

Pubmed IDYearTitleCitations
211874282011Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.114
163329632005The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair.68
174038972007The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends.63
171302402007The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase.56
182638762008Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair.37
204577502010Metnase promotes restart and repair of stalled and collapsed replication forks.32
187908022008The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation.31
214918842011Biochemical characterization of metnase's endonuclease activity and its role in NHEJ repair.26
178773692007Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity.25
211249282010Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.24

Citation

Dessen P

SETMAR (SET domain and mariner transposase fusion gene)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43714/setmar