SGK3 (serum/glucocorticoid regulated kinase family member 3)

2011-04-01  

Identity

HGNC
LOCATION
8q13.1
LOCUSID
ALIAS
CISK,SGK2,SGKL
FUSION GENES

Other Information

Locus ID:

NCBI: 23678
MIM: 607591
HGNC: 10812
Ensembl: ENSG00000104205

Variants:

dbSNP: 23678
ClinVar: 23678
TCGA: ENSG00000104205
COSMIC: SGK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104205ENST00000345714Q96BR1
ENSG00000104205ENST00000345714A0A024R807
ENSG00000104205ENST00000396596Q96BR1
ENSG00000104205ENST00000396596A0A024R807
ENSG00000104205ENST00000518388E5RK28
ENSG00000104205ENST00000519396E5RHR8
ENSG00000104205ENST00000520976Q96BR1
ENSG00000104205ENST00000521152E5RHY6
ENSG00000104205ENST00000521198Q96BR1
ENSG00000104205ENST00000521198A0A024R807
ENSG00000104205ENST00000521960E5RJV7
ENSG00000104205ENST00000522398Q96BR1
ENSG00000104205ENST00000522398A0A024R807
ENSG00000104205ENST00000522629E5RHX2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
FoxO signaling pathwayKEGGhsa04068
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
254588462014SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer.56
210843822011SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells.33
168886202006CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4.31
122180622002Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1).29
167904202006Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.24
257123452015PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.22
154961632004Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases.21
274819352016The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.20
235892912013The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.19
126321892003The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.18

Citation

Dessen P

SGK3 (serum/glucocorticoid regulated kinase family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52187/sgk3