SGPL1 (sphingosine-1-phosphate lyase 1)

2007-02-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
NPHS14,S1PL,SPL
FUSION GENES

Other Information

Locus ID:

NCBI: 8879
MIM: 603729
HGNC: 10817
Ensembl: ENSG00000166224

Variants:

dbSNP: 8879
ClinVar: 8879
TCGA: ENSG00000166224
COSMIC: SGPL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166224ENST00000299297H7BXL7
ENSG00000166224ENST00000373202O95470
ENSG00000166224ENST00000409118H0Y3V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Sphingosine degradationKEGGhsa_M00100
Sphingosine degradationKEGGM00100
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170906862006Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.88
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
191193172009Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.66
253474722014Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.49
145708702004Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.48
281653392017Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.35
227847112012First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.29
244681132014Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.27
181728562008S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.26
213049872011Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase.26

Citation

Dessen P

SGPL1 (sphingosine-1-phosphate lyase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45944/sgpl1