Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25970
MIM: 608937
HGNC: 30417
Ensembl: ENSG00000178188
Variants:
dbSNP: 25970
ClinVar: 25970
TCGA: ENSG00000178188
COSMIC: SH2B1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10026 | aripiprazole | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA162565877 | amisulpride | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA163518919 | paliperidone | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA166123368 | schizoaffective disorder | Disease | ClinicalAnnotation | associated | PD | 28694205 | |
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 28694205 | |
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | 28694205 | |
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation | associated | PD | 28694205 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA450522 | mirtazapine | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA450688 | olanzapine | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA451201 | quetiapine | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 28694205 | |
| PA451846 | valproic acid | Chemical | ClinicalAnnotation | associated | PD | 28694205 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37586323 | 2023 | Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease. | 5 |
| 37586323 | 2023 | Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease. | 5 |
| 31984680 | 2022 | BBOX1-AS1 contributes to colorectal cancer progression by sponging hsa-miR-361-3p and targeting SH2B1. | 20 |
| 34689140 | 2022 | Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion. | 1 |
| 36436143 | 2022 | SH2B1 variants as potential causes of non-syndromic monogenic obesity in a Brazilian cohort. | 0 |
| 31984680 | 2022 | BBOX1-AS1 contributes to colorectal cancer progression by sponging hsa-miR-361-3p and targeting SH2B1. | 20 |
| 34689140 | 2022 | Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion. | 1 |
| 36436143 | 2022 | SH2B1 variants as potential causes of non-syndromic monogenic obesity in a Brazilian cohort. | 0 |
| 31739166 | 2020 | New perspective on SH2B1: An accelerator of cancer progression. | 4 |
| 32251290 | 2020 | Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. | 30 |
| 32365683 | 2020 | Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease. | 7 |
| 33356989 | 2020 | Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma. | 3 |
| 31739166 | 2020 | New perspective on SH2B1: An accelerator of cancer progression. | 4 |
| 32251290 | 2020 | Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease. | 30 |
| 32365683 | 2020 | Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease. | 7 |
Citation
Dessen P
SH2B1 (SH2B adaptor protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-08-01
Online version: http://atlasgeneticsoncology.org/gene/50281/sh2b1
