SH3BP5 (SH3 domain binding protein 5)

2013-11-01  

Identity

HGNC
SH3BP5
LOCATION
3p25.1
LOCUSID
9467
ALIAS
SAB,SH3BP-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9467
MIM: 605612
HGNC: 10827
Ensembl: ENSG00000131370

Variants:

dbSNP: 9467
ClinVar: 9467
TCGA: ENSG00000131370
COSMIC: SH3BP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131370ENST00000366391C9JK30
ENSG00000131370ENST00000383791O60239
ENSG00000131370ENST00000383791A0A024R2G6
ENSG00000131370ENST00000408919O60239
ENSG00000131370ENST00000408919A0A024R2J3
ENSG00000131370ENST00000412806C9J140
ENSG00000131370ENST00000417936C9JNW0
ENSG00000131370ENST00000426925O60239
ENSG00000131370ENST00000426925A0A024R2J3
ENSG00000131370ENST00000450625F8WDU8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
256660172015Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.28
151584512004Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.11
238613912013SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.5
303228862018Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines.4
271848322016Expressions of SH3BP5, LMO3, and SNAP25 in diffuse large B-cell lymphoma cells and their association with clinical features.1
267453402016REI/SH3BP5 protein family: New GEFs for Rab11.0

Citation

Dessen P

SH3BP5 (SH3 domain binding protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53619/sh3bp5