SH3RF1 (SH3 domain containing ring finger 1)

2011-10-01  

Identity

HGNC
LOCATION
4q32.3
LOCUSID
ALIAS
POSH,RNF142,SH3MD2
FUSION GENES

Other Information

Locus ID:

NCBI: 57630
MIM: 618642
HGNC: 17650
Ensembl: ENSG00000154447

Variants:

dbSNP: 57630
ClinVar: 57630
TCGA: ENSG00000154447
COSMIC: SH3RF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154447ENST00000284637Q7Z6J0
ENSG00000154447ENST00000502315D6RHX5
ENSG00000154447ENST00000510806D6RAL3
ENSG00000154447ENST00000511421H0YA90

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
331299502021Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population.0
331299502021Assessing the role of SH3RF1 and SH3RF2 polymorphisms in susceptibility to tuberculosis: A case-control study in the Han Chinese population.0
281294442017Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.5
290577212017POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy.2
281294442017Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.5
290577212017POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy.2
236447442013Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.4
236447442013Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations.4
215861382011Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH.21
215861382011Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH.21
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
209741342010POSH promotes cell survival in Drosophila and in human RASF cells.3
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
209741342010POSH promotes cell survival in Drosophila and in human RASF cells.3
193930812009Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 release.14

Citation

Dessen P

SH3RF1 (SH3 domain containing ring finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52411/sh3rf1