SHC3 (SHC adaptor protein 3)

2003-12-01 Affiliation

Identity

HGNC

SHC3

LOCATION

9q22.1

LOCUSID

53358

ALIAS

N-Shc,NSHC,RAI,SHCC

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 53358
MIM: 605263
HGNC: 18181
Ensembl: ENSG00000148082

Variants:

dbSNP: 53358
ClinVar: 53358
TCGA: ENSG00000148082
COSMIC: SHC3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000148082	ENST00000375831	Q5T7I8
ENSG00000148082	ENST00000375835	Q92529

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
Focal adhesion	KEGG	ko04510
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Insulin signaling pathway	KEGG	ko04910
Glioma	KEGG	ko05214
Chronic myeloid leukemia	KEGG	ko05220
ErbB signaling pathway	KEGG	hsa04012
Focal adhesion	KEGG	hsa04510
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Insulin signaling pathway	KEGG	hsa04910
Glioma	KEGG	hsa05214
Chronic myeloid leukemia	KEGG	hsa05220
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Bacterial invasion of epithelial cells	KEGG	ko05100
Bacterial invasion of epithelial cells	KEGG	hsa05100
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Ras signaling pathway	KEGG	hsa04014
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
Endocrine resistance	KEGG	ko01522
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA30592	MAP3K1	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
36880347	2023	Shc3 facilitates breast cancer drug resistance by interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis.	2
36880347	2023	Shc3 facilitates breast cancer drug resistance by interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis.	2
31944299	2020	The Shc protein Rai enhances T-cell survival under hypoxia.	3
31944299	2020	The Shc protein Rai enhances T-cell survival under hypoxia.	3
29057481	2018	The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells.	2
29330146	2018	Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC.	25
29057481	2018	The Shc protein RAI promotes an adaptive cell survival program in hypoxic neuroblastoma cells.	2
29330146	2018	Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC.	25
25062668	2014	Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.	7
25062668	2014	Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.	7
22311806	2012	Rai is a new regulator of neural progenitor migration and glioblastoma invasion.	18
22311806	2012	Rai is a new regulator of neural progenitor migration and glioblastoma invasion.	18
21046104	2011	The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cell support: a linkage disequilibrium mapping in RAI and CD3EAP.	4
21046104	2011	The importance of a sub-region on chromosome 19q13.3 for prognosis of multiple myeloma patients after high-dose treatment and stem cell support: a linkage disequilibrium mapping in RAI and CD3EAP.	4
19748727	2010	EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas.	8

Citation

Dessen P

SHC3 (SHC adaptor protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42290/shc3

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