SHCBP1 (SHC binding and spindle associated 1)

2016-10-01  

Identity

HGNC
SHCBP1
LOCATION
16q11.2
LOCUSID
79801
ALIAS
PAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79801
MIM: 611027
HGNC: 29547
Ensembl: ENSG00000171241

Variants:

dbSNP: 79801
ClinVar: 79801
TCGA: ENSG00000171241
COSMIC: SHCBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171241ENST00000303383Q8NEM2
ENSG00000171241ENST00000569702I3L3Z1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
238046342013Measles virus nonstructural C protein modulates viral RNA polymerase activity by interacting with host protein SHCBP1.16
271299422016SHCBP1 is over-expressed in breast cancer and is important in the proliferation and apoptosis of the human malignant breast cancer cell line.13
242895562013Targeting SHCBP1 inhibits cell proliferation in human hepatocellular carcinoma cells.11
290209872017SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis.9
275723152016Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma.7
301778362019EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression.5
254863612014SHCBP1 is required for midbody organization and cytokinesis completion.4
297454402018Overexpression of SHCBP1 promotes migration and invasion in gliomas by activating the NF-κB signaling pathway.4
305922902019SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer.2
314721492019SHCBP1 promotes cisplatin induced apoptosis resistance, migration and invasion through activating Wnt pathway.1

Citation

Dessen P

SHCBP1 (SHC binding and spindle associated 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56561/shcbp1