Identity
HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
AIRM-1,AIRM1,CD328,CDw328,D-siglec,QA79,SIGLEC-7,SIGLEC19P,SIGLECP2,p75,p75/AIRM1
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27036
MIM: 604410
HGNC: 10876
Ensembl: ENSG00000168995
Variants:
dbSNP: 27036
ClinVar: 27036
TCGA: ENSG00000168995
COSMIC: SIGLEC7
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | REACTOME | R-HSA-198933 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38141764 | 2024 | The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation. | 0 |
| 38141764 | 2024 | The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation. | 0 |
| 36700509 | 2023 | Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. | 0 |
| 36700509 | 2023 | Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. | 0 |
| 35367830 | 2022 | Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. | 3 |
| 35526487 | 2022 | Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands. | 2 |
| 36211376 | 2022 | Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities. | 5 |
| 35367830 | 2022 | Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. | 3 |
| 35526487 | 2022 | Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands. | 2 |
| 36211376 | 2022 | Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities. | 5 |
| 33248687 | 2021 | The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid. | 3 |
| 33495350 | 2021 | Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. | 43 |
| 33640457 | 2021 | Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells. | 17 |
| 34273636 | 2021 | Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia. | 6 |
| 33248687 | 2021 | The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid. | 3 |
Citation
Dessen P
SIGLEC7 (sialic acid binding Ig like lectin 7)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45703/siglec7
