SIGLEC9 (sialic acid binding Ig like lectin 9)

2003-06-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
CD329,CDw329,FOAP-9,OBBP-LIKE,siglec-9

Other Information

Locus ID:

NCBI: 27180
MIM: 605640
HGNC: 10878
Ensembl: ENSG00000129450

Variants:

dbSNP: 27180
ClinVar: 27180
TCGA: ENSG00000129450
COSMIC: SIGLEC9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129450ENST00000250360Q9Y336
ENSG00000129450ENST00000440804Q9Y336
ENSG00000129450ENST00000599948M0R2D4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191966612009Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response.146
245694532014Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.76
155571782004The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.60
204975502010Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes.57
158271262005Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.53
152922622004Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.51
183253282008Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs.42
252254092014Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.42
275952322016The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.39
218217082011Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.36

Citation

Dessen P

SIGLEC9 (sialic acid binding Ig like lectin 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42296/siglec9