SIK1 (salt inducible kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
DEE30,MSK,SIK,SIK-1,SIK1B,SNF1LK
FUSION GENES

Other Information

Locus ID:

NCBI: 150094
MIM: 605705
HGNC: 11142
Ensembl: ENSG00000142178

Variants:

dbSNP: 150094
ClinVar: 150094
TCGA: ENSG00000142178
COSMIC: SIK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142178ENST00000270162P57059
ENSG00000142178ENST00000644750A0A2R8Y6E4

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196228322009SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
179399932007SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process.32
187255362008TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.27
175655992007TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.22
232561572013Regulation of SIK1 abundance and stability is critical for myogenesis.17
265901482016SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.16
223787832012Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.15
235776672013LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.14
267190722016miR-203 promotes proliferation, migration and invasion by degrading SIK1 in pancreatic cancer.13

Citation

Dessen P

SIK1 (salt inducible kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43496/sik1