SIK2 (salt inducible kinase 2)

2006-10-01  

Identity

HGNC
SIK2
LOCATION
11q23.1
LOCUSID
23235
ALIAS
LOH11CR1I,QIK,SIK-2,SNF1LK2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23235
MIM: 608973
HGNC: 21680
Ensembl: ENSG00000170145

Variants:

dbSNP: 23235
ClinVar: 23235
TCGA: ENSG00000170145
COSMIC: SIK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170145ENST00000304987Q9H0K1
ENSG00000170145ENST00000304987A0A024R3G7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
207081532010SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.53
274780412016Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche.43
233931342013The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.36
224625482012The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes.29
277590072016SIKs control osteocyte responses to parathyroid hormone.24
265901482016SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.16
233227702013Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy.15
255480992015Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer.15
235776672013LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.14

Citation

Dessen P

SIK2 (salt inducible kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43497/sik2