SIRT4 (sirtuin 4)

2014-01-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
SIR2L4

Other Information

Locus ID:

NCBI: 23409
MIM: 604482
HGNC: 14932
Ensembl: ENSG00000089163

Variants:

dbSNP: 23409
ClinVar: 23409
TCGA: ENSG00000089163
COSMIC: SIRT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089163ENST00000202967Q9Y6E7
ENSG00000089163ENST00000536460F5H4X9

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
236637822013The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.188
177151272007Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.125
255258792014Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.108
242964862013SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK.50
243687662014SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.40
260868772015Tumour-suppressive function of SIRT4 in human colorectal cancer.38
271640522016The role of mitochondrial sirtuins in health and disease.36
279418732017SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK-Drp1 pathway.29
253619252014Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients.26
269595562016MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4.25

Citation

Dessen P

SIRT4 (sirtuin 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53767/sirt4