SIRT6 (sirtuin 6)

2007-04-01  

Identity

HGNC
SIRT6
LOCATION
19p13.3
LOCUSID
51548
ALIAS
SIR2L6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51548
MIM: 606211
HGNC: 14934
Ensembl: ENSG00000077463

Variants:

dbSNP: 51548
ClinVar: 51548
TCGA: ENSG00000077463
COSMIC: SIRT6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077463ENST00000337491Q8N6T7
ENSG00000077463ENST00000594279M0R1N9
ENSG00000077463ENST00000597896M0QZ09
ENSG00000077463ENST00000599365M0R0B2
ENSG00000077463ENST00000600938M0R0B2
ENSG00000077463ENST00000601488M0QXA0
ENSG00000077463ENST00000601571M0R1F6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183377212008SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.391
216808432011SIRT6 promotes DNA repair under stress by activating PARP1.257
232177062012The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.216
235529492013SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.203
240522632013Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.196
196257672009Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.144
201575942009SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.123
227009612012NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.103
244387462014Chromatin and beyond: the multitasking roles for SIRT6.99
212242162011Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.96

Citation

Dessen P

SIRT6 (sirtuin 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47142/sirt6