SIX4 (SIX homeobox 4)

2014-11-01  

Identity

HGNC
SIX4
LOCATION
14q23.1
LOCUSID
51804
ALIAS
AREC3

Other Information

Locus ID:

NCBI: 51804
MIM: 606342
HGNC: 10890
Ensembl: ENSG00000100625

Variants:

dbSNP: 51804
ClinVar: 51804
TCGA: ENSG00000100625
COSMIC: SIX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100625ENST00000216513Q9UIU6
ENSG00000100625ENST00000556952G3V2N2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
278211762016The expression profile and clinic significance of the SIX family in non-small cell lung cancer.21
313012902019SIX4 activates Akt and promotes tumor angiogenesis.1

Citation

Dessen P

SIX4 (SIX homeobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/54944/six4