SKA1 (spindle and kinetochore associated complex subunit 1)

2014-06-01  

Identity

HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
C18orf24
FUSION GENES

Other Information

Locus ID:

NCBI: 220134
MIM: 616673
HGNC: 28109
Ensembl: ENSG00000154839

Variants:

dbSNP: 220134
ClinVar: 220134
TCGA: ENSG00000154839
COSMIC: SKA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154839ENST00000285116Q96BD8
ENSG00000154839ENST00000285116A0A024R294
ENSG00000154839ENST00000398452Q96BD8
ENSG00000154839ENST00000398452A0A024R294
ENSG00000154839ENST00000417656Q96BD8
ENSG00000154839ENST00000488454K7EP61
ENSG00000154839ENST00000494518K7EPW0

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192890832009The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility.121
170934952006Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2.97
230850202012The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.87
223715572012Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.57
224836202012Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.52
244135312014Structural basis for microtubule recognition by the human kinetochore Ska complex.34
269817682016The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.28
284958372017Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment.20
287467692017Regulation of spindle and kinetochore-associated protein 1 by antitumor miR-10a-5p in renal cell carcinoma.17
246272412014Spindle and kinetochore-associated protein 1 is overexpressed in gastric cancer and modulates cell growth.16

Citation

Dessen P

SKA1 (spindle and kinetochore associated complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54030/ska1