Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SKP2 (S-phase kinase associated protein 2)

Identity

Alias (NCBI)FBL1
FBXL1
FLB1
p45
HGNC (Hugo) SKP2
HGNC Alias symbFBXL1
FBL1
p45
HGNC Previous nameS-phase kinase-associated protein 2 (p45)
 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
LocusID (NCBI) 6502
Atlas_Id 42307
Location 5p13.2  [Link to chromosome band 5p13]
Location_base_pair Starts at 36152111 and ends at 36184026 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCAM (11q23.3) / SKP2 (5p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;5)(q26;q31) H2AFY/MECOM

External links

Nomenclature
HGNC (Hugo)SKP2   10901
Cards
Entrez_Gene (NCBI)SKP2    S-phase kinase associated protein 2
AliasesFBL1; FBXL1; FLB1; p45
GeneCards (Weizmann)SKP2
Ensembl hg19 (Hinxton)ENSG00000145604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145604 [Gene_View]  ENSG00000145604 [Sequence]  chr5:36152111-36184026 [Contig_View]  SKP2 [Vega]
ICGC DataPortalENSG00000145604
TCGA cBioPortalSKP2
AceView (NCBI)SKP2
Genatlas (Paris)SKP2
SOURCE (Princeton)SKP2
Genetics Home Reference (NIH)SKP2
Genomic and cartography
GoldenPath hg38 (UCSC)SKP2  -     chr5:36152111-36184026 +  5p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SKP2  -     5p13.2   [Description]    (hg19-Feb_2009)
GoldenPathSKP2 - 5p13.2 [CytoView hg19]  SKP2 - 5p13.2 [CytoView hg38]
ImmunoBaseENSG00000145604
genome Data Viewer NCBISKP2 [Mapview hg19]  
OMIM601436   
Gene and transcription
Genbank (Entrez)AB050979 AB050980 AB050981 AK026224 AK291255
RefSeq transcript (Entrez)NM_001243120 NM_005983 NM_032637
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SKP2
Alternative Splicing GalleryENSG00000145604
Gene ExpressionSKP2 [ NCBI-GEO ]   SKP2 [ EBI - ARRAY_EXPRESS ]   SKP2 [ SEEK ]   SKP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SKP2 [ Firebrowse - Broad ]
GenevisibleExpression of SKP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6502
GTEX Portal (Tissue expression)SKP2
Human Protein AtlasENSG00000145604-SKP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13309   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13309  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13309
Splice isoforms : SwissVarQ13309
PhosPhoSitePlusQ13309
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box-like_dom_sf    F-box_dom    Leu-rich_rpt_Cys-con_subtyp    LRR_dom_sf   
Domain families : Pfam (Sanger)F-box-like (PF12937)   
Domain families : Pfam (NCBI)pfam12937   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)SKP2
Blocks (Seattle)SKP2
PDB (RSDB)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
PDB Europe1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
PDB (PDBSum)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
PDB (IMB)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
Structural Biology KnowledgeBase1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
SCOP (Structural Classification of Proteins)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
CATH (Classification of proteins structures)1FQV    1FS1    1FS2    1LDK    2ASS    2AST   
SuperfamilyQ13309
Human Protein Atlas [tissue]ENSG00000145604-SKP2 [tissue]
Peptide AtlasQ13309
HPRD03256
IPIIPI00178899   IPI00013294   IPI01012086   IPI00163172   IPI00967750   IPI00968046   IPI00968062   
Protein Interaction databases
DIP (DOE-UCLA)Q13309
IntAct (EBI)Q13309
BioGRIDSKP2
STRING (EMBL)SKP2
ZODIACSKP2
Ontologies - Pathways
QuickGOQ13309
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein polyubiquitination  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  cytosol  cytosol  viral process  protein deubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of intracellular estrogen receptor signaling pathway  identical protein binding  regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  innate immune response  positive regulation of smooth muscle cell proliferation  defense response to virus  regulation of cell cycle  ubiquitin protein ligase activity  protein K48-linked ubiquitination  cellular response to cell-matrix adhesion  positive regulation of protein polyubiquitination  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein polyubiquitination  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  cytosol  cytosol  viral process  protein deubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of intracellular estrogen receptor signaling pathway  identical protein binding  regulation of apoptotic process  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  innate immune response  positive regulation of smooth muscle cell proliferation  defense response to virus  regulation of cell cycle  ubiquitin protein ligase activity  protein K48-linked ubiquitination  cellular response to cell-matrix adhesion  positive regulation of protein polyubiquitination  
Pathways : KEGGFoxO signaling pathway    Cell cycle    Ubiquitin mediated proteolysis    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Small cell lung cancer   
NDEx NetworkSKP2
Atlas of Cancer Signalling NetworkSKP2
Wikipedia pathwaysSKP2
Orthology - Evolution
OrthoDB6502
GeneTree (enSembl)ENSG00000145604
Phylogenetic Trees/Animal Genes : TreeFamSKP2
HOGENOMQ13309
Homologs : HomoloGeneSKP2
Homology/Alignments : Family Browser (UCSC)SKP2
Gene fusions - Rearrangements
Fusion : QuiverSKP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSKP2 [hg38]
dbVarSKP2
ClinVarSKP2
MonarchSKP2
1000_GenomesSKP2 
Exome Variant ServerSKP2
GNOMAD BrowserENSG00000145604
Varsome BrowserSKP2
Genomic Variants (DGV)SKP2 [DGVbeta]
DECIPHERSKP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSKP2 
Mutations
ICGC Data PortalSKP2 
TCGA Data PortalSKP2 
Broad Tumor PortalSKP2
OASIS PortalSKP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSKP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSKP2
Mutations and Diseases : HGMDSKP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SKP2
DgiDB (Drug Gene Interaction Database)SKP2
DoCM (Curated mutations)SKP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SKP2 (select a term)
intoGenSKP2
Cancer3DSKP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601436   
Orphanet
DisGeNETSKP2
MedgenSKP2
Genetic Testing Registry SKP2
NextProtQ13309 [Medical]
GENETestsSKP2
Target ValidationSKP2
Huge Navigator SKP2 [HugePedia]
ClinGenSKP2
Clinical trials, drugs, therapy
MyCancerGenomeSKP2
Protein Interactions : CTD
Pharm GKB GenePA35801
PharosQ13309
Clinical trialSKP2
Miscellaneous
canSAR (ICR)SKP2 (select the gene name)
HarmonizomeSKP2
DataMed IndexSKP2
Probes
Litterature
PubMed466 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSKP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:37:26 CET 2021
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