SLC10A2 (solute carrier family 10 member 2)

2007-02-01  

Identity

HGNC
LOCATION
13q33.1
LOCUSID
ALIAS
ASBT,IBAT,ISBT,NTCP2,PBAM

Other Information

Locus ID:

NCBI: 6555
MIM: 601295
HGNC: 10906
Ensembl: ENSG00000125255

Variants:

dbSNP: 6555
ClinVar: 6555
TCGA: ENSG00000125255
COSMIC: SLC10A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125255ENST00000245312Q12908

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Recycling of bile acids and saltsREACTOMER-HSA-159418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21900104, 23441093
PA445425Prostatic NeoplasmsDiseaseClinicalAnnotationassociatedPD20038957
PA449383docetaxelChemicalClinicalAnnotationassociatedPD20038957
PA451644thalidomideChemicalClinicalAnnotationassociatedPD20038957

References

Pubmed IDYearTitleCitations
202019242010Genome-wide association study of alcohol dependence implicates a region on chromosome 11.159
152390982004Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.56
167498552006Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target.41
186684392008Bile acid transporters in health and disease.41
213419872011Genetic polymorphisms in Na+-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations.30
259021432015Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide.29
120551952002Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha.26
153501252004Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).26
254182802015The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B.24
122202242003Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter.23

Citation

Dessen P

SLC10A2 (solute carrier family 10 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43699/slc10a2