SLC15A1 (solute carrier family 15 member 1)

2007-02-01 Affiliation

Identity

HGNC

SLC15A1

LOCATION

13q32.2

LOCUSID

6564

ALIAS

HPECT1,HPEPT1,PEPT1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6564
MIM: 600544
HGNC: 10920
Ensembl: ENSG00000088386

Variants:

dbSNP: 6564
ClinVar: 6564
TCGA: ENSG00000088386
COSMIC: SLC15A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000088386	ENST00000376503	P46059
ENSG00000088386	ENST00000376503	B2CQT6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein digestion and absorption	KEGG	ko04974
Protein digestion and absorption	KEGG	hsa04974
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Proton/oligopeptide cotransporters	REACTOME	R-HSA-427975

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA449688	fluvastatin	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
15521010	2004	hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells.	79
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18668438	2008	Peptide transporters and their roles in physiological processes and drug disposition.	57
14561585	2003	Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease.	30
20558765	2010	PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells.	28
21762661	2011	The PepT1-NOD2 signaling pathway aggravates induced colitis in mice.	25
18466105	2008	Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.	23
19462432	2009	PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.	22
16963449	2007	Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors.	19
22959800	2012	Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro.	19

Citation

Dessen P

SLC15A1 (solute carrier family 15 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46274/slc15a1