SLC15A2 (solute carrier family 15 member 2)

2014-11-01 Affiliation

Identity

HGNC

SLC15A2

LOCATION

3q13.33

LOCUSID

6565

ALIAS

PEPT2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6565
MIM: 602339
HGNC: 10921
Ensembl: ENSG00000163406

Variants:

dbSNP: 6565
ClinVar: 6565
TCGA: ENSG00000163406
COSMIC: SLC15A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163406	ENST00000295605	Q16348
ENSG00000163406	ENST00000469013	C9IZ38
ENSG00000163406	ENST00000489711	Q16348

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Proton/oligopeptide cotransporters	REACTOME	R-HSA-427975

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444447	Carcinoma, Hepatocellular	Disease	ClinicalAnnotation	associated		PD
PA7000	sorafenib	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
18668438	2008	Peptide transporters and their roles in physiological processes and drug disposition.	57
20173083	2010	Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.	44
15282265	2004	Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions.	31
18474668	2008	Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.	22
22950754	2013	Expression profile and functional activity of peptide transporters in prostate cancer cells.	15
18713951	2008	Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.	14
19723536	2009	Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure.	13
19723536	2009	Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure.	13

Citation

Dessen P

SLC15A2 (solute carrier family 15 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73284/slc15a2