SLC16A11 (solute carrier family 16 member 11)

2014-11-01  

Identity

HGNC
SLC16A11
LOCATION
17p13.1
LOCUSID
162515
ALIAS
MCT 11,MCT11

Other Information

Locus ID:

NCBI: 162515
MIM: 615765
HGNC: 23093
Ensembl: ENSG00000174326

Variants:

dbSNP: 162515
ClinVar: 162515
TCGA: ENSG00000174326
COSMIC: SLC16A11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174326ENST00000308009Q8NCK7
ENSG00000174326ENST00000447225C9JRM8
ENSG00000174326ENST00000574600I3L431
ENSG00000174326ENST00000662352A0A590UJX4

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
243903452014Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.138
286661192017Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.35
258399362015Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes.14
281019332017Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study.6
264877852016Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.5
304752252019The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes.1

Citation

Dessen P

SLC16A11 (solute carrier family 16 member 11)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73289/slc16a11