SLC16A7 (solute carrier family 16 member 7)

2008-05-01 Affiliation

Identity

HGNC

SLC16A7

LOCATION

12q14.1

LOCUSID

9194

ALIAS

MCT2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9194
MIM: 603654
HGNC: 10928
Ensembl: ENSG00000118596

Variants:

dbSNP: 9194
ClinVar: 9194
TCGA: ENSG00000118596
COSMIC: SLC16A7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000118596	ENST00000261187	O60669
ENSG00000118596	ENST00000261187	A0A024RBB2
ENSG00000118596	ENST00000546459	F8VVU7
ENSG00000118596	ENST00000547379	O60669
ENSG00000118596	ENST00000547379	A0A024RBB2
ENSG00000118596	ENST00000548444	F8VS95
ENSG00000118596	ENST00000548610	F8W0N3
ENSG00000118596	ENST00000549033	F8W1M4
ENSG00000118596	ENST00000549305	F8VYZ2
ENSG00000118596	ENST00000549465	F8W0U4
ENSG00000118596	ENST00000549928	F8VVU7
ENSG00000118596	ENST00000550062	F8VQS4
ENSG00000118596	ENST00000551877	F8VXG4
ENSG00000118596	ENST00000552024	O60669
ENSG00000118596	ENST00000552024	A0A024RBB2
ENSG00000118596	ENST00000552432	O60669
ENSG00000118596	ENST00000552432	A0A024RBB2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Proton-coupled monocarboxylate transport	REACTOME	R-HSA-433692

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443433	Arthritis, Juvenile Rheumatoid	Disease	ClinicalAnnotation	associated		PD
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
18188595	2008	Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.	80
20454640	2010	Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.	67
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
21787388	2011	Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.	57
19876643	2010	Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.	42
25243493	2014	Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.	29
19834535	2009	Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.	27
21680735	2011	Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II.	25
17502341	2007	The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells.	24
28281525	2017	Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.	21

Citation

Dessen P

SLC16A7 (solute carrier family 16 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50149/slc16a7