Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6571
MIM: 193001
HGNC: 10935
Ensembl: ENSG00000165646
Variants:
dbSNP: 6571
ClinVar: 6571
TCGA: ENSG00000165646
COSMIC: SLC18A2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000165646 | ENST00000644641 | Q05940 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447215 | Psychotic Disorders | Disease | ClinicalAnnotation | associated | PD | 27272046 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 22947179 | |
| PA448687 | bupropion | Chemical | ClinicalAnnotation | associated | PD | 22947179 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 27272046 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38081299 | 2024 | Transport and inhibition mechanisms of human VMAT2. | 4 |
| 38163846 | 2024 | Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines. | 5 |
| 38081299 | 2024 | Transport and inhibition mechanisms of human VMAT2. | 4 |
| 38163846 | 2024 | Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines. | 5 |
| 36318270 | 2023 | Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals. | 8 |
| 36318270 | 2023 | Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals. | 8 |
| 34774656 | 2022 | Comparisons of vesicular monoamine transporter type 2 signals in Parkinson's disease and parkinsonism secondary to carbon monoxide poisoning. | 1 |
| 35524772 | 2022 | Sclerosing Paragangliomas: Correlations of Histological Features with Patients' Genotype and Vesicular Monoamine Transporter Expression. | 0 |
| 34774656 | 2022 | Comparisons of vesicular monoamine transporter type 2 signals in Parkinson's disease and parkinsonism secondary to carbon monoxide poisoning. | 1 |
| 35524772 | 2022 | Sclerosing Paragangliomas: Correlations of Histological Features with Patients' Genotype and Vesicular Monoamine Transporter Expression. | 0 |
| 34758845 | 2021 | VMAT2 availability in Parkinson's disease with probable REM sleep behaviour disorder. | 6 |
| 34758845 | 2021 | VMAT2 availability in Parkinson's disease with probable REM sleep behaviour disorder. | 6 |
| 30471418 | 2019 | Decreased pallidal vesicular monoamine transporter type 2 availability in Parkinson's disease: The contribution of the nigropallidal pathway. | 7 |
| 30983500 | 2019 | VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence. | 5 |
| 31317476 | 2019 | Synaptic Vesicle Protein 2 and Vesicular Monoamine Transporter 1 and 2 Are Expressed in Neuroblastoma. | 3 |
Citation
Dessen P
SLC18A2 (solute carrier family 18 member A2)
Atlas Genet Cytogenet Oncol Haematol. 2007-11-01
Online version: http://atlasgeneticsoncology.org/gene/49830/slc18a2
