SLC18A2 (solute carrier family 18 member A2)

2007-11-01 Affiliation

Identity

HGNC

SLC18A2

LOCATION

10q25.3

LOCUSID

6571

ALIAS

PKDYS2,SVAT,SVMT,VAT2,VMAT2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6571
MIM: 193001
HGNC: 10935
Ensembl: ENSG00000165646

Variants:

dbSNP: 6571
ClinVar: 6571
TCGA: ENSG00000165646
COSMIC: SLC18A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165646	ENST00000644641	Q05940

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Parkinson's disease	KEGG	hsa05012
Synaptic vesicle cycle	KEGG	ko04721
Synaptic vesicle cycle	KEGG	hsa04721
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Serotonin Neurotransmitter Release Cycle	REACTOME	R-HSA-181429
Dopamine Neurotransmitter Release Cycle	REACTOME	R-HSA-212676
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Na+/Cl- dependent neurotransmitter transporters	REACTOME	R-HSA-442660

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA447215	Psychotic Disorders	Disease	ClinicalAnnotation	associated	PD	27272046
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	22947179
PA448687	bupropion	Chemical	ClinicalAnnotation	associated	PD	22947179
PA452233	antipsychotics	Chemical	ClinicalAnnotation	associated	PD	27272046

References

Pubmed ID	Year	Title	Citations
17652604	2007	Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration.	151
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18045777	2008	A network of dopaminergic gene variations implicated as risk factors for schizophrenia.	54
21041608	2011	Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.	48
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
11279528	2001	Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes.	42
17233532	2006	Vesicular monoamine transporter 2: role as a novel target for drug development.	40
18288090	2008	Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study.	38
23363473	2013	Brain dopamine-serotonin vesicular transport disease and its treatment.	37

Citation

Dessen P

SLC18A2 (solute carrier family 18 member A2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49830/slc18a2