SLC1A6 (solute carrier family 1 member 6)

2014-11-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
EAAT4
FUSION GENES

Other Information

Locus ID:

NCBI: 6511
MIM: 600637
HGNC: 10944
Ensembl: ENSG00000105143

Variants:

dbSNP: 6511
ClinVar: 6511
TCGA: ENSG00000105143
COSMIC: SLC1A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105143ENST00000221742P48664
ENSG00000105143ENST00000430939E7EV13
ENSG00000105143ENST00000544886P48664
ENSG00000105143ENST00000594383M0R1V3
ENSG00000105143ENST00000595863M0QY32
ENSG00000105143ENST00000597262M0R106
ENSG00000105143ENST00000598504P48664
ENSG00000105143ENST00000599636M0R2V7
ENSG00000105143ENST00000600144M0R063
ENSG00000105143ENST00000601761M0R0B5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173609172007The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.47
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
205195052010A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).15
223027962012Neuronal glutamate transporters regulate glial excitatory transmission.14
174420442007EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase.11
215720472011Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4.10
172218392007Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.7
172218392007Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.7
224242432013Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.2

Citation

Dessen P

SLC1A6 (solute carrier family 1 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73312/slc1a6