Identity
HGNC
LOCATION
6q25.3
LOCUSID
ALIAS
HOCT1,OCT1,oct1_cds
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6580
MIM: 602607
HGNC: 10963
Ensembl: ENSG00000175003
Variants:
dbSNP: 6580
ClinVar: 6580
TCGA: ENSG00000175003
COSMIC: SLC22A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10804 | imatinib | Chemical | ClinicalAnnotation, VipGene | associated | PK | PD | 19584153, 23223357, 18398725, 24589908, 28762371, 29427770, 30237583, 30713339 |
| PA151958383 | Gastrointestinal Stromal Tumors | Disease | ClinicalAnnotation | associated | PD | 28762371 | |
| PA161925594 | tropisetron | Chemical | VipGene | associated | 20921968 | ||
| PA164712420 | Anticholinergics | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164712431 | Antiemetics And Antinauseants | Chemical | VariantAnnotation | associated | PK | PD | 20921968 |
| PA164712697 | Dopamine agonists | Chemical | ClinicalAnnotation | associated | PD | ||
| PA166129521 | sedation | Disease | VariantAnnotation | associated | PD | 23835420 | |
| PA166131379 | o-desmethyltramadol | Chemical | VariantAnnotation | associated | PK | 27082504 | |
| PA166157178 | rs12208357 | Variant | VipGene | associated | |||
| PA166157196 | rs34059508 | Variant | VipGene | associated | |||
| PA166157197 | rs34130495 | Variant | VipGene | associated | 14576340 | ||
| PA166157216 | rs72552763 | Variant | VipGene | associated | |||
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PD | 19381165, 19898263 | |
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation | associated | PK | PD | 17111267, 22735389 |
| PA443928 | Dizziness | Disease | VariantAnnotation | associated | PD | 23835420 | |
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | associated | PD | 23835420 | |
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 27610747 |
| PA444354 | Headache | Disease | VariantAnnotation | associated | PD | 23835420 | |
| PA445048 | Nausea | Disease | VariantAnnotation | associated | PD | 23835420 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 29427770, 30237583, 30713339 |
| PA445208 | Pain | Disease | VariantAnnotation | associated | PK | 27082504 | |
| PA445254 | Parkinson Disease | Disease | ClinicalAnnotation | associated | PD | ||
| PA446171 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Disease | ClinicalAnnotation | associated | PK | PD | 24589908 |
| PA448360 | amantadine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449088 | codeine | Chemical | VariantAnnotation | ambiguous | PK | PD | 23835420 |
| PA450163 | lamivudine | Chemical | Pathway | associated | |||
| PA450164 | lamotrigine | Chemical | ClinicalAnnotation | associated | PK | PD | 27610747 |
| PA450213 | levodopa | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450395 | metformin | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VipGene | associated | PK | PD | 19536068, 19898263, 20690652, 21989078, 17111267, 17609683, 19381165, 19898263, 21989078, 22722338, 22735389, 24624919, 26700958, 27859023, 28380657, 28834135, 29352482 |
| PA450550 | morphine | Chemical | VariantAnnotation, VipGene | associated | PK | 23835420 | |
| PA451124 | proguanil | Chemical | VariantAnnotation | associated | PK | 29882324 | |
| PA451316 | selegiline | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451735 | tramadol | Chemical | ClinicalAnnotation, VipGene | associated | PK | 21562485 | |
| PA7000 | sorafenib | Chemical | MultilinkAnnotation, VipGene | associated | 23532667 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38605354 | 2024 | THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma. | 1 |
| 38605354 | 2024 | THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma. | 1 |
| 36853844 | 2023 | Pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) in newly diagnosed Indian type 2 diabetes patients undergoing metformin monotherapy. | 0 |
| 37821493 | 2023 | Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. | 4 |
| 36853844 | 2023 | Pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) in newly diagnosed Indian type 2 diabetes patients undergoing metformin monotherapy. | 0 |
| 37821493 | 2023 | Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. | 4 |
| 34545025 | 2022 | Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes. | 1 |
| 34902340 | 2022 | Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. | 6 |
| 34927264 | 2022 | Genetic variants in SLC22A1 are related to serum lipid levels in Mexican women. | 1 |
| 35216120 | 2022 | Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1. | 7 |
| 35413990 | 2022 | OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer. | 6 |
| 35456416 | 2022 | The Role of SLC22A1 and Genomic Ancestry on Toxicity during Treatment in Children with Acute Lymphoblastic Leukemia of the Amazon Region. | 3 |
| 35469921 | 2022 | Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1. | 5 |
| 34545025 | 2022 | Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes. | 1 |
| 34902340 | 2022 | Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. | 6 |
Citation
Dessen P
SLC22A1 (solute carrier family 22 member 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-05-01
Online version: http://atlasgeneticsoncology.org/gene/51461/slc22a1
